3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23765688.
- Also identified by DOI 10.1002/adma.201301016 and PMC identifier 3954574.
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Abstract
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions.
Medical subject headings
- Decanoates
- Glycerol
- Myoblasts
- Myocardium
- Polymers
- Tissue Engineering
- Tissue Scaffolds