Role of interleukin 23 signaling in Clostridium difficile colitis.
basic_science · Level V
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- Record sourced from PubMed, PMID 23776194.
- Also identified by DOI 10.1093/infdis/jit277 and PMC identifier 3749013.
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Abstract
Clostridium difficile is currently the leading cause of hospital-acquired infections in the United States. Here, we observed increased interleukin 23 (IL-23) protein levels in human colon biopsy specimens positive for C. difficile toxins, compared with levels in negative controls (P = .008) We also investigated the role of IL-23 during C. difficile infection, using 2 distinct murine models. Mice lacking IL-23 signaling had a significant increase in survival (100% [12 mice]), compared with control mice (16.7%-50% [12 mice]). These data suggest a new potential drug target for human C. difficile treatment and indicate the first link between IL-23 and disease severity during murine infection.
Medical subject headings
- Clostridioides difficile
- Clostridium Infections
- Colitis
- Interleukin-23
- Signal Transduction