A multivariate method for detecting genetic linkage, with application to a pedigree with an adverse lipoprotein phenotype.
other · Level V
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- Record sourced from PubMed, PMID 2378349.
- Also identified by PMC identifier 1683708.
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Abstract
The robust or model-free method for detecting linkage developed by Haseman and Elston for data from sib pairs is extended to incorporate observations of multiple traits on each individual. A method is proposed that estimates the linear function that results in the strongest correlation between the squared pair differences in the trait measurements and identity by descent at a marker locus. The method is illustrated by the study of apolipoprotein and cholesterol levels in individuals from a large family that had many members diagnosed with coronary heart disease.
Medical subject headings
- Coronary Disease
- Genetic Linkage
- Lipoproteins
- Models, Genetic