Injectable autogenous corium: technique development in the rat model.

Abstract

Difficult facial rhytides have been treated with injectable bovine collagen. To our knowledge, there has been no reported use of injectable autogenous collagen. We studied several techniques using homogenization of dermis in the rat model. Commercial tissue homogenizers produced a fine emulsification, which serial clinical and histological examinations showed to be largely resorbed. A household blender produced coarse homogenates, which persisted 5 to 6 months; however, most of the implants eventually were resorbed. We conclude that coarse homogenates of dermis persist longer as implants than do fine homogenates in the rat model.