"License to kill" reflects joint action of CD4 and CD8 T cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23785048.
- Also identified by DOI 10.1158/1078-0432.CCR-13-1432.
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Abstract
The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-cell types to promote cancer cell killing.
Medical subject headings
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Epitopes, T-Lymphocyte
- Kinesins
- Neoplasms
- Peptides