Reconstructed stem cell nanoghosts: a natural tumor targeting platform.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23786263.
- Also identified by DOI 10.1021/nl401376w.
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Abstract
The ultimate goal in cancer therapy is achieving selective targeting of cancer cells. We report a novel delivery platform, based on nanoghosts (NGs) produced from the membranes of mesenchymal stem cells (MSCs). Encompassing MSC surface molecules, the MSC-NGs retained MSC-specific in vitro and in vivo tumor targeting capabilities and were cleared from blood-filtering organs. MSC-NGs were found to be biocompatible. Systemic administration of drug loaded MSC-NGs demonstrated 80% inhibition of human prostate cancer.
Medical subject headings
- Cell Membrane
- Mesenchymal Stem Cells
- Nanocapsules
- Peptide Fragments
- Prostatic Neoplasms
- Receptors, TNF-Related Apoptosis-Inducing Ligand