Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23788402.
- Also identified by DOI 10.1002/adhm.201300110 and PMC identifier 3955951.
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Abstract
Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.
Medical subject headings
- Amines
- Thrombomodulin