Multiplexed plasmon sensor for rapid label-free analyte detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23789876.
- Also identified by DOI 10.1021/nl401354f.
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Abstract
Efficient and cost-effective multiplexed detection schemes for proteins in small liquid samples would bring drastic advances to fields like disease detection or water quality monitoring. We present a novel multiplexed sensor with randomly deposited aptamer functionalized gold nanorods. The spectral position of plasmon resonances of individual nanorods, monitored by dark-field spectroscopy, respond specifically to different proteins. We demonstrate nanomolar sensitivity, sensor recycling, and the potential to upscale to hundreds or thousands of targets.
Medical subject headings
- Biosensing Techniques
- Nanotechnology
- Protein Array Analysis
- Proteins
- Surface Plasmon Resonance