Aging well with a little wine and a good clock.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23791169.
- Also identified by DOI 10.1016/j.cell.2013.05.055 and PMC identifier 3840422.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Age-related decline in mammalian circadian rhythm has been recognized for decades, but the underlying molecular mechanisms have remained elusive. In this issue of Cell, Chang and Guarente use brain-specific SIRT1 knockout mice and transgenic mice overexpressing SIRT1 to develop an enticing model for how SIRT1 helps maintain the robustness of the aging circadian clock.
Medical subject headings
- Aging
- Circadian Clocks
- Sirtuin 1
- Suprachiasmatic Nucleus