Carving axon arbors to fit: master directs one kinase at a time.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23791171.
- Also identified by DOI 10.1016/j.cell.2013.05.047.
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Abstract
Pyramidal neurons in the cortex require the master kinase LKB1 for early axon specification. Courchet et al. now uncover a later role for LKB1 and its tango with the downstream effector kinase NUAK1 in controlling terminal axonal branching through influencing mitochondrial motility in axons.
Medical subject headings
- Axons
- Mitochondria
- Neurons
- Protein Kinases
- Protein Serine-Threonine Kinases
- Repressor Proteins
- Signal Transduction