Pyruvate as a pivot point for oncogene-induced senescence.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23791173.
- Also identified by DOI 10.1016/j.cell.2013.06.001 and PMC identifier 3753778.
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Abstract
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically.
Medical subject headings
- Cellular Senescence
- Mitochondria
- Oncogenes
- Pyruvate Dehydrogenase Complex