Linc2GO: a human LincRNA function annotation resource based on ceRNA hypothesis.
basic_science · Level V
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- Record sourced from PubMed, PMID 23793747.
- Also identified by DOI 10.1093/bioinformatics/btt361.
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Abstract
Large numbers of long intergenic non-coding RNA (lincRNA) have been detected through high-throughput sequencing technology. However, currently we still know very little about their functions. Therefore, a lincRNA function annotation database is needed to facilitate the study in this field. In this article, we present Linc2GO, a web resource that aims to provide comprehensive functional annotations for human lincRNA. MicroRNA-mRNA and microRNA-lincRNA interaction data were integrated to generate lincRNA functional annotations based on the 'competing endogenous RNA hypothesis'. To the best of our knowledge, Linc2GO is the first database that makes use of the 'competing endogenous RNA hypothesis' to predict lincRNA functions. Freely available at http://www.bioinfo.tsinghua.edu.cn/~liuke/Linc2GO/index.html
Medical subject headings
- Databases, Nucleic Acid
- Molecular Sequence Annotation
- RNA, Long Noncoding