Fluorescent nanoparticle delivered dsRNA toward genetic control of insect pests.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23794475.
- Also identified by DOI 10.1002/adma.201301201.
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Abstract
A fluorescent cationic core-shell nanoparticle efficiently enters into cells with high transfection efficacy. A FNP/CHT10-dsRNA complex is orally fed to insect pests and knocks down a midgut-specific chitinase gene of the Asian corn borer, which leads to death. This is the first report on the genetic control of insect pests through a non-viral gene delivery system to knock down key developmental gene expression.
Medical subject headings
- Drosophila
- Fluorescent Dyes
- Genetic Vectors
- Insecticides
- Nanoparticles
- RNA, Double-Stranded