The open access malaria box: a drug discovery catalyst for neglected diseases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23798988.
- Also identified by DOI 10.1371/journal.pone.0062906 and PMC identifier 3684613.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the Malaria Box. Half of these compounds were selected based on their drug-like properties and the others as molecular probes. These can now be requested as a pharmacological test set by malaria biologists, but importantly by groups working on related parasites, as part of a program to make both data and compounds readily available. In this paper, the analysis and selection methodology and characteristics of the compounds are described.
Medical subject headings
- Antimalarials
- Drug Discovery
- Malaria, Falciparum