The contentious ontogeny of fibrosis in the kidney.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23812360.
- Also identified by DOI 10.1038/ki.2013.107.
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Abstract
Arguably, no cell biology related to the loss of renal function is more debated than the ontogeny of fibrosis in the kidney. Recent studies suggest that the fibroblasts depositing most of the excess extracellular matrix in diseased kidneys derive from epithelial cells versus pericytes resident within the kidney. Reich et al. now contend that circulating bone marrow-derived fibrocytes independent of monocyte lineages are an important source of fibrogenic cells recruited to the kidney following injury.
Medical subject headings
- Chemotaxis
- Collagen
- Kidney
- Kidney Diseases
- Monocytes