Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23813808.
- Also identified by DOI 10.1002/adma.201301917 and PMC identifier 3898629.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce efficient gene knockdown both in vitro and in vivo. Histology studies and liver function tests reveal that no apparent toxicity is caused by these nanoparticles at doses over two orders of magnitude.
Medical subject headings
- Aminoglycosides
- Gene Transfer Techniques
- Lipids
- RNA, Small Interfering