Scalable manufacture of built-to-order nanomedicine: spray-assisted layer-by-layer functionalization of PRINT nanoparticles.

Morton, Stephen W; Herlihy, Kevin P; Shopsowitz, Kevin E; Deng, Zhou J; Chu, Kevin S; Bowerman, Charles J; Desimone, Joseph M; Hammond, Paula T · Adv Mater · 2013

basic_science · Level V

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Abstract

Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.

Medical subject headings