Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles.
basic_science · Level V
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- Record sourced from PubMed, PMID 23821753.
- Also identified by DOI 10.1073/pnas.1310431110 and PMC identifier 3718127.
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Abstract
The synthesis of polypeptides on solid phase via mediation by isonitriles is described. The acyl donor is a thioacid, which presumably reacts with the isonitrile to generate a thio-formimidate carboxylate mixed anhydride intermediate. Applications of this chemistry to reiterative solid-phase peptide synthesis as well as solid-phase fragment coupling are described.
Medical subject headings
- Amides
- Nitriles
- Peptides
- Solid-Phase Synthesis Techniques