Concentrations of cefixime in bronchial mucosa and sputum after three oral multiple dose regimens.

Baldwin, D R; Andrews, J M; Ashby, J P; Wise, R; Honeybourne, D · Thorax · 1990

case_series · Level IV

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Abstract

In a study of 58 patients the concentrations of cefixime, a new oral cephem antibiotic, in bronchial mucosa were 35-40% of the concentrations found in simultaneously collected serum samples. The antibiotic was often undetectable in sputum despite a highly sensitive assay.

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