Sweet nothings: sensing of sugar metabolites controls T cell function.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23823473.
- Also identified by DOI 10.1016/j.cmet.2013.06.009 and PMC identifier 3749232.
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Abstract
Signal transduction and metabolism cooperate to control cell fate, but mechanisms that link metabolic substrates to functional decisions are elusive. Now, Chang et al. (2013) in Cell provide a mechanism whereby available sugars dictate metabolic pathways in activated T cells and direct a nonmetabolic regulatory function of glyceraldehyde-3-phosphate dehydrogenase.
Medical subject headings
- Glycolysis
- Lymphocyte Activation
- Oxidative Phosphorylation
- T-Lymphocytes