Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: control of size, shape, and drug release.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23824544.
- Also identified by DOI 10.1002/adma.201301033.
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Abstract
This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.
Medical subject headings
- Antineoplastic Agents
- Carmustine
- Drug Delivery Systems
- Lactic Acid
- Microfluidics
- Polyglycolic Acid