Axonal alignment and enhanced neuronal differentiation of neural stem cells on graphene-nanoparticle hybrid structures.
basic_science · Level V
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- Record sourced from PubMed, PMID 23824715.
- Also identified by DOI 10.1002/adma.201302219 and PMC identifier 4189106.
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Abstract
Human neural stem cells (hNSCs) cultured on graphene-nanoparticle hybrid structures show a unique behavior wherein the axons from the differentiating hNSCs show enhanced growth and alignment. We show that the axonal alignment is primarily due to the presence of graphene and the underlying nanoparticle monolayer causes enhanced neuronal differentiation of the hNSCs, thus having great implications of these hybrid-nanostructures for neuro-regenerative medicine.
Medical subject headings
- Axons
- Cell Differentiation
- Graphite
- Nanoparticles
- Neural Stem Cells