Genetic variations of GAK in two Chinese Parkinson's disease populations: a case-control study.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 23826309.
- Also identified by DOI 10.1371/journal.pone.0067506 and PMC identifier 3691170.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cyclin G-associated kinase (GAK) modifies α-synuclein expression levels and affects the susceptibility of Parkinson's disease (PD). The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations. To date there is only one data with regards to ethnic Chinese from Mainland China. Here, we conducted a case-control study in two independent cohorts of Han Chinese populations from Taiwan and Singapore to validate this association. A total of 1,755 subjects (871 PD patients and 884 controls) were recruited. The results showed that neither the CT, TT genotypes nor the minor allele T of SNP rs1564282 were associated with PD among the subjects from Taiwan and Singapore as well as in the pooled analysis. Differences in our study population with regards to published literature may be due to epigenetic factors and gene-gene or gene-environmental interactions. Further studies in other Chinese populations will be of interest to validate these findings.
Medical subject headings
- Asian People
- Genetic Variation
- Intracellular Signaling Peptides and Proteins
- Parkinson Disease
- Protein Serine-Threonine Kinases