Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23827702.
- Also identified by DOI 10.1016/j.stem.2013.06.012.
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Abstract
Pathways that regulate epigenetic control of stem cell identity are critical to the molecular etiology of cancer. In back-to-back articles in Cell and Cell Stem Cell, Song et al. identify miR-22 as both a repressor of TET proteins and a powerful oncogene in the mammary epithelium and hematopoietic system.
Medical subject headings
- Breast Neoplasms
- Cell Transformation, Neoplastic
- Chromatin Assembly and Disassembly
- DNA-Binding Proteins
- Epithelial-Mesenchymal Transition
- Gene Expression Regulation, Neoplastic
- Hematologic Neoplasms
- Hematopoietic Stem Cells
- MicroRNAs
- Myelodysplastic Syndromes
- Neoplasm Metastasis
- Neoplastic Stem Cells
- Proto-Oncogene Proteins