Notching up MYC gives a LIC.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23827704.
- Also identified by DOI 10.1016/j.stem.2013.06.008 and PMC identifier 3746020.
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Abstract
In a recent issue of Cell, King et al. (2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia-initiating cells (LICs) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of MYC abolishes LIC activity with broader therapeutic implications.
Medical subject headings
- Cell Cycle Proteins
- F-Box Proteins
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins c-myc
- Ubiquitin-Protein Ligases