-Oh no! hiPSCs misplace their 5hmCs.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23827705.
- Also identified by DOI 10.1016/j.stem.2013.06.007 and PMC identifier 3753777.
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Abstract
hiPSCs and hESCs are thought to display subtle genetic and epigenetic variability. Recently in Nature Cell Biology, Wang et al. (2013) demonstrated a role for TET1 during reprogramming of human cells and showed that hiPSCs lack appropriate 5hmC marks in subtelomeric regions, contributing to epigenetic variation common to hiPSCs.
Medical subject headings
- 5-Methylcytosine
- Cytosine
- DNA-Binding Proteins
- Induced Pluripotent Stem Cells
- Proto-Oncogene Proteins