Automated QuantMap for rapid quantitative molecular network topology analysis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23828784.
- Also identified by DOI 10.1093/bioinformatics/btt390 and PMC identifier 3753568.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The previously disclosed QuantMap method for grouping chemicals by biological activity used online services for much of the data gathering and some of the numerical analysis. The present work attempts to streamline this process by using local copies of the databases and in-house analysis. Using computational methods similar or identical to those used in the previous work, a qualitatively equivalent result was found in just a few seconds on the same dataset (collection of 18 drugs). We use the user-friendly Galaxy framework to enable users to analyze their own datasets. Hopefully, this will make the QuantMap method more practical and accessible and help achieve its goals to provide substantial assistance to drug repositioning, pharmacology evaluation and toxicology risk assessment. http://galaxy.predpharmtox.org mats.gustafsson@medsci.uu.se or ola.spjuth@farmbio.uu.se Supplementary data are available at Bioinformatics online.
Medical subject headings
- Pharmaceutical Preparations
- Protein Interaction Mapping
- Software