Induced regeneration--the progress and promise of direct reprogramming for heart repair.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23836233.
- Also identified by DOI 10.1038/nm.3225 and PMC identifier 3862032.
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Abstract
Regeneration of cardiac tissue has the potential to transform cardiovascular medicine. Recent advances in stem cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools to advance this goal. In this Review we examine key developments in the generation of new cardiomyocytes in vitro as well as the exciting progress that has been made toward in vivo reprogramming of cardiac tissue. We also address controversies and hurdles that challenge the field.
Medical subject headings
- Cellular Reprogramming
- Heart
- Induced Pluripotent Stem Cells
- Regeneration
- Regenerative Medicine