DNA helicases involved in DNA repair and their roles in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23842644.
- Also identified by DOI 10.1038/nrc3560 and PMC identifier 4538698.
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Abstract
Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, the complexity of the DNA damage response leaves us with unanswered questions regarding how helicase-dependent DNA repair pathways are regulated and coordinated with cell cycle checkpoints. Further studies may open the door to targeting helicases in order to improve cancer treatments based on DNA-damaging chemotherapy or radiation.
Medical subject headings
- DNA Helicases
- DNA Repair
- Neoplasms