The DREAM complex: master coordinator of cell cycle-dependent gene expression.
review · Level V
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- Record sourced from PubMed, PMID 23842645.
- Also identified by DOI 10.1038/nrc3556 and PMC identifier 3986830.
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Abstract
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
Medical subject headings
- Cell Cycle
- Cell Cycle Proteins
- Cell Transformation, Neoplastic
- Gene Expression Regulation
- Retinoblastoma Protein
- Transcription Factors