The use of biatain Ag in hard-to-heal venous leg ulcers: meta-analysis of randomised controlled trials.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 23843984.
- Also identified by DOI 10.1371/journal.pone.0067083 and PMC identifier 3699549.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Venous leg ulcers are common, troublesome, and their failure to heal is often related to a heavy bio-burden. Ionized silver has both anti-inflammatory and antimicrobial properties. The ulcer healing properties of the silver releasing foam dressing Biatain Ag has been examined in 4 randomized controlled trials (RCTs). To evaluate ulcer healing through a meta-analytic approach after treatment with either Biatain Ag or a non-active dressing. 685 subjects with pure or mixed hard-to-heal venous leg ulcers were included in the meta-analysis. Biatain Ag showed a significant treatment effect (p<0.0001), responder rate (p<0.001), and healing rate (p = 0.002). The meta-analysis of the 4 RCTs provided statistical significant evidence to support the use of Biatain Ag dressing in treatment of hard-to-heal venous leg ulcers.
Medical subject headings
- Anti-Infective Agents, Local
- Silver Compounds
- Varicose Ulcer
- Wound Healing