Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23847204.
- Also identified by DOI 10.1073/pnas.1218131110 and PMC identifier 3732919.
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Abstract
We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate.
Medical subject headings
- B-Lymphocytes
- Bone Marrow
- Cell Movement
- Extracellular Matrix
- Spleen