Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23857588.
- Also identified by DOI 10.1002/adma.201301713.
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Abstract
By combining upconversion nanoparticles with the cisplatin (IV) prodrug we have demonstrated that a stable and multifunctional drug delivery system can be designed that will both reduce the drawbacks of cisplatin and give insight in to its in vitro/in vivo imaging. The up/down-conversion fluorescence are detectable and show obvious co-localization, demonstrating that the nanoparticles are rather stable inside cells and retain the UCNPs and block copolymer.
Medical subject headings
- Antineoplastic Agents
- Cisplatin
- Drug Delivery Systems
- Fluorescent Dyes
- Nanocomposites
- Optical Imaging
- Polymers