Child Neurology: Pediatric seizures with hyaline astrocytic inclusions.
case_report · Level V
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- Record sourced from PubMed, PMID 23858415.
- Also identified by DOI 10.1212/WNL.0b013e31829bfe54 and PMC identifier 3770161.
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Abstract
Astrocytic dysfunction is implicated in epilepsy through many proposed molecular mechanisms, but there is also a clinicopathologic entity of epilepsy featuring astrocytic inclusions.<sup>1</sup> At least 17 cases of early-onset epilepsy with eosinophilic, hyaline astrocytic inclusions have been reported since the early 1990s.<sup>2–8</sup> Most of these cases also involve developmental delay.<sup>2–8</sup> The diagnosis is made by neuropathologic analysis that demonstrates brightly eosinophilic, hyaline, refractile astrocytic inclusions seen under light microscopy with hematoxylin & eosin stain.<sup>2–8</sup> We review the clinicopathologic entity of pediatric epilepsy with hyaline astrocytic inclusions and report an illustrative case.
Medical subject headings
- Astrocytes
- Brain
- Hyalin
- Inclusion Bodies
- Seizures