Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis.
meta_analysis · Level I
Where this comes from
- Record sourced from PubMed, PMID 23861880.
- Also identified by DOI 10.1371/journal.pone.0068295 and PMC identifier 3702579.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87-0.93, Poverall = 2.1×10(-10)). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.
Medical subject headings
- Arthritis, Rheumatoid
- CD3 Complex
- Genetic Association Studies
- Polymorphism, Single Nucleotide