Antiinflammatory effects of apoptotic cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23863635.
- Also identified by DOI 10.1172/JCI69344 and PMC identifier 3696541.
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Abstract
Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.
Medical subject headings
- Apoptosis
- Inflammation Mediators