Aging: seeking mitonuclear balance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23870118.
- Also identified by DOI 10.1016/j.cell.2013.06.046.
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Abstract
Metabolic imbalances accompany the aging process in many organisms, and signaling mechanisms that allay or prevent these imbalances can extend lifespan. Two recent studies by Auwerx and colleagues, including one in this issue, identify a conserved signaling network centered on mitochondrial stress responses that promotes longevity in response to changes in mitochondrial translation and NAD(+) metabolism.
Medical subject headings
- Forkhead Transcription Factors
- Longevity
- Mitochondria
- NAD
- Signal Transduction
- Unfolded Protein Response