Propofol-related infusion syndrome heralding a mitochondrial disease: case report.
case_report · Level V
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- Record sourced from PubMed, PMID 23873972.
- Also identified by DOI 10.1212/WNL.0b013e3182a1aa78 and PMC identifier 3776462.
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Abstract
Propofol-related infusion syndrome (PRIS) is a rare but catastrophic complication of propofol use. It is clinically characterized by metabolic acidosis, rhabdomyolysis, arrhythmias, myocardial failure, renal failure, and hepatomegaly, and may lead to death.<sup>1</sup> Some risk factors are associated with PRIS, namely young age, critical illness, high fat intake, catecholamine or steroid use, inborn error of fatty acid oxidation, propofol doses exceeding 4–5 mg/kg/hour, and duration of use exceeding 48 hours.<sup>1</sup> Some evidence also suggests that PRIS is related to a mitochondrial toxicity of propofol.<sup>2,3</sup>
Medical subject headings
- Arrhythmias, Cardiac
- Mitochondrial Diseases
- Propofol
- Renal Insufficiency
- Rhabdomyolysis