LHRH-PE40 fusion protein tethered silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23878059.
- Also identified by DOI 10.1002/adma.201301217.
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Abstract
Docyanine green (ICG) and LHRH-PE40 fusion protein are tethered onto drug carriers of silica nanorattles for imaging-guided tumor-specific drug delivery and bimodal therapy. The synergistic therapeutic effect of toxin PE40 and the chemotherapeutic drug docetaxel (Dtxl), specifically directed by LHRH to cancer, improves cancer treatment. Simultaneously, ICG enables real-time monitoring of the silica nanocomposites and therapeutic response.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Exotoxins
- Gonadotropin-Releasing Hormone
- Lung Neoplasms
- Nanocomposites
- Recombinant Fusion Proteins
- Silicon Dioxide