Antinociception induced by intraperitoneal injection of gentamicin in rats and mice.

Abstract

Intraperitoneal administration of gentamicin sulfate (5-800 micrograms/kg), but not gentamicin base (23-92 micrograms/kg) produced antinociception in rats and mice, as assessed by the tail-flick, carrageenan-induced articular incapacity tests, and hot-plate tests. The AD50 s in rats (tail-flick test) and mice (hot-plate test) were 11.48 and 147.9 micrograms/kg, respectively, but doses of 200-800 micrograms/kg were required to reduce the hyperalgesia induced in rats by carrageenan. In both species, bell-shaped dose-response curves were obtained, indicating that high doses of gentamicin had little or no effect. Non-effective doses of gentamicin failed to produce a significant increase in morphine antinociception in either rodent species. The possible involvement of N-type voltage-sensitive Ca2+ channels in the mechanism of antinociception induced by gentamicin is considered.