Increased circulating platelet microparticles as a potential biomarker in asthma.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 23889600.
- Also identified by DOI 10.1111/all.12190.
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Abstract
Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P = 0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P = 0.005) but not after adjustments (P = 0.117). We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.
Medical subject headings
- Asthma
- Blood Platelets
- Cell-Derived Microparticles
- Up-Regulation