Just a trim, please: refining ER degradation through deubiquitination.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23890819.
- Also identified by DOI 10.1016/j.cell.2013.07.008 and PMC identifier 5423715.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
ER-associated degradation clears the secretory pathway of misfolded proteins and mediates the regulated degradation of some ER resident proteins. Only a minor increase in the interaction between a protein and a ubiquitin ligase is sufficient to signal substrate degradation. Zhang et al. have identified deubiquitination as a signal amplifier.
Medical subject headings
- Endopeptidases
- Endoplasmic Reticulum
- Membrane Proteins