Accurate and universal delineation of prokaryotic species.
basic_science · Level V
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- Record sourced from PubMed, PMID 23892899.
- Also identified by DOI 10.1038/nmeth.2575.
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Abstract
The exponentially increasing number of sequenced genomes necessitates fast, accurate, universally applicable and automated approaches for the delineation of prokaryotic species. We developed specI (species identification tool; http://www.bork.embl.de/software/specI/), a method to group organisms into species clusters based on 40 universal, single-copy phylogenetic marker genes. Applied to 3,496 prokaryotic genomes, specI identified 1,753 species clusters. Of 314 discrepancies with a widely used taxonomic classification, >62% were resolved by literature support.
Medical subject headings
- DNA Barcoding, Taxonomic
- Genetic Markers
- Genome
- Phylogeny
- Prokaryotic Cells