Rapidly-dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach.
basic_science · Level V
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- Record sourced from PubMed, PMID 23893866.
- Also identified by DOI 10.1002/adma.201300526 and PMC identifier 4262250.
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Abstract
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.