Rheumatoid arthritis. Triple therapy or etanercept after methotrexate failure in RA?

van Vollenhoven, Ronald F; Chatzidionysiou, Katerina · Nat Rev Rheumatol · 2013

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Abstract

Since the 1990s, patients with rheumatoid arthritis have been treated with at least one DMARD. Methotrexate, which is usually the first-line treatment, elicits good or even excellent clinical results in 20–30% of patients—but in most patients it does not. Thus, an important question is what to do after methotrexate failure.

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