Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection.

Gould, Carolyn V; Edwards, Jonathan R; Cohen, Jessica; Bamberg, Wendy M; Clark, Leigh Ann; Farley, Monica M; Johnston, Helen; Nadle, Joelle et al. · Clin Infect Dis · 2013

retrospective_cohort · Level III

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Abstract

Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging from 43% to 67% in CDI incidence attributable to changing from toxin enzyme immunoassays to NAAT. CDI surveillance requires adjustment for testing methods.

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