Transcriptomic profiling in childhood H1N1/09 influenza reveals reduced expression of protein synthesis genes.
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- Record sourced from PubMed, PMID 23901082.
- Also identified by DOI 10.1093/infdis/jit348 and PMC identifier 3805235.
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Abstract
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
Medical subject headings
- Gene Expression Profiling
- Gene Expression Regulation
- Influenza A Virus, H1N1 Subtype
- Influenza, Human
- Protein Biosynthesis