The calcium-sensing receptor directly regulates proximal tubular functions.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23903415.
- Also identified by DOI 10.1038/ki.2013.128.
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Abstract
Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions.
Medical subject headings
- Acid-Base Equilibrium
- Calcium
- Kidney Tubules, Proximal
- Receptors, Calcium-Sensing
- Receptors, G-Protein-Coupled