Natural killer cell response to BK virus infection in polyoma virus-associated nephropathy of renal transplant recipients.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23903417.
- Also identified by DOI 10.1038/ki.2013.148.
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Abstract
The mechanisms of injury and advantage secured by opportunistic infection with polyoma virus in renal transplant patients are not completely known. Patient virus-specific T cells play a large role in elimination of reactivated polyoma virus. Natural killer (NK) cells are early responders in antiviral response. Inflammatory NK-cell antiviral responses involve activation receptors such as killer-cell immunoglobulin-like receptors (KIRs) interacting with host-cell major histocompatibility complex class I molecules, altering cell sensitivity to lysis by NK cells.
Medical subject headings
- BK Virus
- Kidney Diseases
- Kidney Transplantation
- Killer Cells, Natural
- Polyomavirus Infections
- Receptors, KIR3DS1
- Tumor Virus Infections