Has the circulating permeability factor in primary FSGS been found?
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23903418.
- Also identified by DOI 10.1038/ki.2013.204 and PMC identifier 3733481.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A circulating permeability factor has long been implicated in the pathogenesis of primary focal segmental glomerulosclerosis (FSGS). Evidence in animal models and now in several cohorts of patients with primary FSGS suggests a role for the soluble urokinase-type plasminogen activator receptor (suPAR) as a biomarker and perhaps as a contributing factor. Confirmation of these findings might lead to new diagnostic and therapeutic strategies for FSGS as well as a better understanding of podocyte dysfunction.
Medical subject headings
- Glomerulosclerosis, Focal Segmental
- Receptors, Urokinase Plasminogen Activator